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LATEST NEWS

Approved Marine Drugs
© 2021-2023 Marine Pharmacology

August 2023 

  • All links were checked and working properly.

  • Clinical trial numbers were updated accordingly.
    o    Cy
    tarabine US clinical trials from 434 to 432 and European clinical trials from 127 to 126
    o    Vidarabine US clinical trials from 23 to 22
    o    Eribulin Mesylate US clinical trials from 66
     to 68 
    o    Brentuximab vedotin US clinical trials from 84 to 82 
    o    Trabectedin US clinical trials from 21 to 20
    o    Polatuzumab vedotin US clinical trials from 37 to 39
    o    Disitamab vedotin US clincal trials from 47
     to 51 and Chinese clinical trials from 8 to 10

July 2023 

  • All links were checked and working properly.

  • Clinical trial numbers were updated accordingly.
    o    Cytarabine US clinical trials from 440 to 434 and Chinese clinical trials from 53 to 54
    o    Vidarabine US clinical trials from 24 to 23
    o    Omega-3-acid ethyl esters US clinical trials from 20 to 18
    o    Eicosapentaenoic acid ethyl ester US clinical trials from 4 to 7
    o    Eribulin Mesylate US clinical trials from 33 to 66 and Chinese clinical trials from 9 to 10
    o    Brentuximab vedotin US clinical trials from 71 to 84 
    o    Trabectedin US clinical trials from 19 to 21
    o    Polatuzumab vedotin US clinical trials from 25 to 37
    o    Enfortumab vedotin US clinical trials from 21 to 28, European clinical trials from 10 to 11, and Chinese clinical trials from none to 1
    o    Lurbinectedin US clinical trials from 23 to 24
    o    Disitamab vedotin US clincal trials from 32 to 47 and Chinese clinical trials from 7 to 8

June 2023 

  • All links were checked and working except the Chinese Clinical Trials links. Chinese clinical trials links were checked for all and updated to:

  • The year-of-FDA-approval link for the Blenrep withdrawal was updated.

  • Panobinostat (Farydak®) and Belantamab Mafodotin-blmf (Blenrep™) were withdrawn from accelerated approval and removed from the table. 

  • It was noted in the drug table that Omega-3-carboxylic acid (Epanova®) was discontinued in 2021.

  • The Molecular Target was corrected for Panobinostat to deacetylase, Plitidepsin to eEF1A2, Polutuzumab vedotin to CD79b and microtubules, Enfortumab vedotin-ejfv to Nectin-4 and microtubules, Disitimab vedotin to HER2 and microtubules, and Tisotumab vedotin-tftv to TF and microtubules.

  • Clinical trial numbers were updated accordingly.

    • Cytarabine US clinical trials from 428 to 440 and Chinese clinical trials from 48 to 53.

    • Vidarabine US clinical trials from 23 to 24.

    • Omega-3-acid ethyl esters US clinical trials from 22 to 20.

    • Eribulin mesylate US clinical trials from 35 to 33, European clinical trials from 21 to 22, and Chinese clinical trials from 8 to 9.

    • Trabectedin US clinical trials from 20 to 19.

    • Enfortumab vedotin US clinical trials from 19 to 21 and European clinical trials from 9 to 10.

    • Lurbinectedin US clinical trials from 21 to 23.

    • Belantamab mafodotin US clinical trials from 34 to 39 and European clinical trials from 17 to 19.

    • Disitamab vedotin US clinical trials from 29 to 32 and Chinese clinical trials from 6 to 7.

    • Tisotumab vedotin US clinical trials from 3 to 4.

April 2023 

  • All links were checked and are working properly. 

    • ​In January we changed Arasena A to the current link, which was not working in early April. At the time of our meeting, it was working again, so we did not to change the link. 

  • Clinical trial numbers were updated accordingly.

    • Cytaribine US clinical trials from 425 to 428, European clinical trials from 125 to 127, and Chinese clinical trials from 47 to 48

    • Vidarabine US clinical trials from 21 to 23

    • Ziconotide US clinical trials from 1 to 2

    • Omega-3-acid ethyl esters US clinical trials from 24 to 22

    • Eicosapentaenoic acid ethyl ester US clinical trials from 5 to 4

    • Eribulun Mesulate US clinical trials from 36 to 35

    • Brentuximab vedotin US clinical trials from 70 to 69, European clinical trials from 39 to 40

    • Trabectedin US clinical trials from 21 to 20, European clinical trials from 23 to 22

    • Panbinostat US clinical trials from 12 to 11

    • Plitidepsin US clinical trials from 2 to 1

    • Polutuzumab vedotin US clinical trials from 23 to 25

    • Enfortumab vedotin US clinical trials from 18 to 19

    • Lurbinectedin European clinical trials from 4 to 5

    • Disitimab vedotin US clinical trials from 28 to 29

March 2023 

  • All links were checked and are working properly. 

  • Clinical trial numbers were updated accordingly.  

    • Cytaribine US clinical trials from 427 to 425

    • Vidarabine US clinical trials from 22 to 21

    • Ziconitide US Clinical trials from 2 to 1

    • Eicosapentaenoic acid ethyl ester European clinical trials from 4 to 2

    • Brentuximab vedotin US clinical trials from 72 to 70, European clinical trials from 39 to 38

    • Polatuzumab vedotin US clinical trials from 22 to 23

    • Lurbinectedin US clinical trials from 20 to 21

    • Belantamab mafodotin US clinical trials from 33 to 34

    • Disitimab vedotin US Clinical trials from 26 to 28 and Chinese clinical trials from 4 to 6

February 2023 

  • All links were checked and are working properly. 

  • Clinical trial numbers were updated accordingly.  ​​

    • Cytarabine US clinical trials went from 426 to 427, European clinical trials from 126 to 125, and Chinese clinical trials from 46 to 47

    • Omega-3-carboxylic acid trials were updated from 8 to 0, accounting only for ongoing studies

    • Erubilin mesylate Chinese clinical trials were updated from 7 to 8

    • Panbinostat US clinical trials were updated from 13 to 12

    • Plitidepsin US clinical trials were updated from 1 to 2

    • Enfortumab vedotin US clinical trials were udated from 19 to 18

    • Lurbinectedin US clinical trials were updated from 21 to 20

January 2023 

  • All links were checked and working properly except the Arasena A prescription link. The Arasena A link https://www.nlm.nih.gov/pubs/techbull/ja22/ja22_pubchem.html was updated December 16th, and no longer shows the prescribing information. It has been updated to https://www.gnhindia.com/products/nz-drugs/vira-a-solution-for-infusion-200-mg-ml/.

  • Chinese cliinical trials links are again working.

  • Clinical trial numbers were updated accordingly.

    • Cytarabine US clinical trials from 430 to 426, European clincal trials from 128 to 126, and Chinese clinical trials from 45 to 46​

    • Omega-3-acid ethyl esters US clinical trials from 23 to 24

    • Brentuximab vedotin US clinical trials from 73 to 72 and European clinical trials from 40 to 39

    • Panbinostat US clincal trials from 14 to 13 and European clinical trials from 8 to 7

    • Plitidepsin European clinical trials from 2 to 3

    • Polatuzumab vedotin European clinical trials from 3 to 2

    • Enfortumab vedotin US clinical trials from 18 to 19

    • Lurbinectedin US clinical trials from 17 to 21 and European clincal trials from 3 to 4

    • Disitimab vedotin Chinese clinical trials from 3 to 4

December 2022 

  • All the links have been checked and were working properly, except links addressing compounds in Chinese clinical trials. We are working with Dr. Jinbo Yang's group to update these links.

  • The approved marine-derived pharmaceutical Belantamab Mafoditin-blmf  (Blenrep) withdrawal process was initiated on 11-22-2022, following the request of the FDA. The agency's request was based on the previously announced outcome of the Phase III DREAMM-3 confirmatory trial, which did not meet the requirements of the FDA accelerated approval regulations. (https://www.gsk.com/en-gb/media/press-releases/gsk-provides-update-on-blenrep-us-marketing-authorisation/).   

  • Clinical trials numbers were updated accordingly. 

    • Cytarabine European clinical trials from 132 to 128​

    • Vidarabine US clinical trials from 48 to 22

    • Omega-3-acid ethyl esters US clinical trials from 24 to 23

    • Erubilin mesylate US clinical trials from 38 to 36

    • Panbinostat US clinical trials from 15 to 14 

    • Polutuzumab vedotin US clinical trials from 23 to 22

    • Belantamab mafodotin US clinical trials from 31 to 33 and European clinical trials from 14 to 17

    • Disitimab vedotin US clinical trials from 23 to 26

October 2022 

  • All the links have been checked and were working properly.

  • The number of current clinical trials was updated accordingly.

    • Cytarabine Chinese clinical trials from 43 to 45​

    • Vidarabine US clinical trials from 49 to 48

    • Erubilin mesylate US clinical trials from 36 to 38

    • Brentuximab vedotin US clinical trials from 74 to 73 and European clinical trials from 42 to 40

    • Trabectedin US clinical trials from 22 to 21

    • Enfortumab vedotin US clinical trials from 17 to 18

    • Lurbinectedin US clinical trials from 18 to 17

    • Belantamab mafodotin US clinical trials from 29 to 31

    • Disitimab vedotin US clinical trials from 20 to 23 and Chinese clinical trials from 1 to 3

September 2022 

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